The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature

EL Fletcher; JA Phipps; MM Ward; KA Vessey; JL Wilkinson-Berka

Journal article

The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature

EL Fletcher, JA Phipps, MM Ward, KA Vessey, JL Wilkinson-Berka

Progress in Retinal and Eye Research | Published : 2010

DOI: 10.1016/j.preteyeres.2010.03.003

Abstract

Renin-Angiotensin System is classically recognized for its role in the control of systemic blood pressure. However, the retina is recognized to have all the components necessary for angiotensin II formation, suggestive of a role for Angiotensin II in the retina that is independent of the systemic circulation. The most well described effects of Angiotensin II are on the retinal vasculature, with roles in vasoconstriction and angiogenesis. However, it is now emerging that Angiotensin II has roles in modulation of retinal function, possibly in regulating GABAergic amacrine cells. In addition, Angiotensin II is likely to have effects on glia. Angiotensin II has also been implicated in retinal va..

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University of Melbourne Researchers

Erica Fletcher Author

Kirstan Vessey Author

Jenny Wilkinson-Berka Author

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Grants

Funding Acknowledgements

[ "This work was supported by the National Health and Medical Research Council of Australia (NHMRC grant #566815 to ELF. and #350224, and #299974 to J.W-B. & E.L.F.). J.W-B. is an NHMRC Senior Research Fellow B. JAP is a CJ Martin Fellow of the NH&MRC.", "The work described in this review has been supported by the grants from the National Health and Medical Research Council of Australia, The Juvenile Diabetes Research Foundation and Diabetes Australia Research Trust. We would also like to sincerely thank the extraordinary efforts of our laboratory members both past and present who have contributed in various ways to the work that is described here." ]